New heterocycloalkylbenzocyclobutane and heteroarylbenzocyclobutane compounds, a process for their preparation and pharmaceutical compositions containing them

摘要

Heterocycloalkyl and heteroaryl benzocyclobutane derivatives (I) are new. Heterocycloalkyl and heteroaryl benzocyclobutane derivatives (I), their isomers and salts, acids and bases are new. dotted line = single or double bond; n = 1-6; R1, R2 = H, 1-6C alkyl, aryl, arylalkyl, cycloalkyl, cycloalkyl alkyl, 2-6C alkenyl or alkynyl, heterocycloalkyl, heterocycloalkyl alkyl, heteroaryl, or heteroaryl alkyl; X = -CH=CH-, -O-, -S(O)m-, or -N(R3)-; n = 0-2; R3 = H, 1-6C alkyl, aryl, arylalkyl, cycloalkyl, cycloalkyl alkyl, or 2-6C alkenyl or alkynyl; Y = CH or CH2 depending on whether it is linked by a single or double bond, or it may be O when X is O; T = 3-12C mono- or polycyclic cycloalkyl in which one of the C atoms may be replaced by O, Se, SOp, R3 or SiR4R5; p = 0-2; R4, R5 = 1-6C alkyl. Within the definition of (I), aryl groups may be phenyl, biphenyl, naphthyl, dihydronaphthyl, tetrahydronaphthyl, indanyl, indenyl, or benzocyclobutyl, each of which may be substituted by one or more of the following: halogen, 1-6C alkyl or alkoxy, OH, NO2, CN, 1-6C trihaloalkyl, NH2, or mono- or di-alkylamino, heteroaryl groups comprise an aryl group as defined above containing 1-3 hetero atoms (O, N, S) in the cyclic system and optionally substituted as before, cycloalkyl groups may be mono- or polycyclic of 3-12 members, optionally containing unsaturations and optionally substituted as before, and heterocycloalkyl groups comprise a cycloalkyl groups as defined that may have one or more unsaturations and containing 1-3 heteroatoms (O, N, S) in the ring. An Independent claim is also included for preparations of (I).