Heterocycloalkylbenzocyclobutane compounds and heteroarylbenzocyclobutane compounds, process for their preparation and pharmaceutical compositions containing the same

摘要

Invention Patent: "DEHETEROCYCLE-ALKYLBENZOCYCLE-BUTANE AND DEHETEROARYLBENZOCYCLE-BUTANE COMPOUNDS, PROCESS FOR SUPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME". Compounds of formula (I): where: - sym indicates a single bond or a double bond; - n is an integer from 1 to 6, inclusive; - R ~ 1 ~ and R ~ 2 ~, represent a group selected from a hydrogen atom, a linear or branched (C ~ 1 ~ -C ~ 6 ~) alkyl group, an aryl group, an arylalkyl group, a cycloalkyl group, a cycloalkylalkyl group, an alkenyl group, an alkynyl group, a heterocycloalkyl group, a heterocycloalkylalkyl group, a heteroaryl group and a heteroarylalkyl group; X represents a selected group of -CH = CH-, an oxygen atom, an S (O) ~ m ~ group, where m is an integer from 0 to 2 inclusive, and NR ~ 3 ~, where R ~ 3 ~ represents a group as defined in the description; - Y represents a CH or CH ~ 2 ~ group, depending on whether sym indicates a single bond or a double bond or may have the additional meaning of an oxygen atom, when X represents an oxygen atom; - T represents a monocyclic or polycyclic (C ~ 3 ~ -C ~ 10 ~) group optionally containing within the ring system an oxygen atom, a selenium atom, a group of formula S (O) ~ p ~, NR ~ 3 ~ or SiR ~ 4 ~ R ~ 5 ~, where p, R ~ 3 ~, R ~ 4 ~ and R ~ 5 ~ are as defined in the description; - their isomers and their addition salts with a pharmaceutically acceptable acid or base.