Epoxidation process of cis-double bonds

摘要

Production of macrocyclic monoepoxides containing at least one double bond, involves addition of a macrocyclic aliphatic hydrocarbon to hydrogen peroxide in the presence of a homogeneous catalyst system comprising an oxidation catalyst, preferably polyoxometallate of tungsten or molybdenum and a Group 14-16 element with a phase transfer catalyst. A process for the production of macrocyclic monoepoxides (I) containing at least one double bond, prepared from a macrocyclic aliphatic hydrocarbon, having at least one cis double bond and the presence of at least one other trans double bond, by addition of hydrogen peroxide in the presence of a catalyst, comprises processing in two liquid phases and use of a homogeneous catalyst system comprising an oxidation catalyst and a phase transfer catalyst whereby the oxidation catalyst is a polyoxometallate of tungsten or molybdenum and a Group 14-16 element, preferably germanium, tin, lead, arsenic, antimony, bismuth, selenium, tellurium or polonium.