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PREPARATION OF RED BLOOD CELLS WITH A MODIFIED LEVEL OF BLOOD GROUP ANTIGEN EXPRESSION AND THEIR USE IN THE QUALITY CONTROL OF BLOOD TYPING REAGENTS
PREPARATION OF RED BLOOD CELLS WITH A MODIFIED LEVEL OF BLOOD GROUP ANTIGEN EXPRESSION AND THEIR USE IN THE QUALITY CONTROL OF BLOOD TYPING REAGENTS
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机译:具有修饰的血型抗原表达水平的红色血细胞的制备及其在血型鉴定试剂质量控制中的应用
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摘要
A method for the preparation of red blood cells expressing reduced levels of blood group antigens using at least one immunodominant sugar modifying enzyme, for example alpha-N-acetylgalactosaminidase or alpha-galactosidase. The red blood cells produced preferably express a level of antigen substantially equivalent to the clinically significant threshold for the antigen. Red blood cells produced according to said method are used for the quality control of blood typing reagents and the calibration of testing systems to give accurate and standardized determinations of blood group types.
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