KNOCK IN TRANSGENIC MAMMAL CONTAINING A NON-FUNCTIONAL N-TERMINUS OF KV BETA 1.1 SUBUNIT

摘要

This invention provides a transgenic mammal containing a defective beta 1 subunit (Kv1) of a voltage sensitive potassium channel, where the Kv1 subunit is unable to confer N-type inactivation of the K but retains the ability to co-associate with Kv1 family -subunits and thereby enhance channel surface expression. Preferably the Kv1.1 gene encoding Kv1 subunit has a mutation in all or a portion of codons 1-70 of its inactivation domain. The transgenic mammal is useful as a model for psychiatric and neurological disorders to identify anxiolytic compounds and pro-cognitive functions. The invention also provides for methods for screening and evaluating test compounds for their ability to modulate Kv1.1 activity, specifically for inactivation of a potassium channel or for co-association with -subunits.