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ALGORITHM FOR ESTIMATING THE OUTCOME OF INFLAMMATION FOLLOWING INJURY OR INFECTION
ALGORITHM FOR ESTIMATING THE OUTCOME OF INFLAMMATION FOLLOWING INJURY OR INFECTION
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机译:估计伤害或感染后炎症结果的算法
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摘要
A mathematical prognostic in which changes in a number of physiologically significant factors are measured and interpolated to determine a "damage function" incident to bacterial infection or other serious inflammation. By measuring a large number of physiologically significant factors including, but not limited to, Interleukin 6 (IL6), Interleukin 10 (IL10), Nitric Oxide (NO), and others, it is possible to predict life versus death by the damage function, dD/dt, which measures and interpolates differential data for a plurality of factors. In mammals, an IL6/NO ratio 8 at 12 hours post infection is highly predictive (60%) of mortality; also in mammals, an IL6/NO ratio 4 at 24 hours post infection is highly predictive (52%) of mortality; and an IL6/IL10 ratio in mammals of 7.5 at 24 hours post infection is highly predictive (68%) of mortality.
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