Targeting chronic and evolving neuroinflammation following traumatic brain injury to improve long-term outcomes: insights from microglial-depletion models

摘要

Microglia,the resident innate immune cells of the central nervous system(CNS),play important roles in brain development,maintenance,and disease.As brain sentinels,microglia adopt a surveillant state in healthy tissue characterized by a ramified scanning morphology that maintains CNS homeostasis and contributes to learningassociated synaptic plasticity.