Treatment of pain with combinations of nalbuphine and Kappa opioid receptor agonists and antagosnistas opioid receptor

摘要

Methods and compositions to treat, manage, or relieve pain in a subject (preferably a Mammal, preferably a human being and more) that comprise the Administration of an agonist Action (i.e., centralCrosses the blood Brain Barrier) of an opioid receptor antagonist and an action so that apioides central analgesia achieved by this administration is higher than that achieved with the Administration of the opioid receptor agonist or antagonist apioides alone.Preferably, the opioid receptor is nalbuphine or a Salt or prodrug of nalbuphine, and opioid antagonist is a Salt or prodrug of naloxone or nalbuphine, and opioid antagonist naloxone or is a Salt or prodrug of noloxona. Preferred methods include the Administration of Administration (For example intranasal mucosal or Lung) and intravenosoa.Other recipients include opioid pentazocine and butorphanol.Claim 1: a method to treat Pain comprising administering to a indiiduo mucosal way that need such treatment (0.1 mg) of 0.8 mg of an opioid antagonist clohidrato of Ao a cantidaad equivalent of a Free Base, prodrug, or a mixture of non hydrochloride, L Os, antagonist of Opioid and opioid antagonist, where this is Naltrexone, naloxoneMethylnaltrexone, nalmefene, nalorphine, levalorfan, or oxilorfan cyprenorphine, and (b) an amount of Free based clohidrato, prodrug, non -, hydrochloride, or a mixture of mimsos of nalbuphine, which results in a Greater analgesia to the Administration of the opioid antagonist clohidrato Or that nalbuphine alone.Claim 3: a method according to claim 1, wherein the opioid antagonist naloxone or is a Salt or prodrug of naloxone.Claim 40: a Pharmaceutical composition which comprises (a) 0.1 to 0.8 mg mg a hydrochloride opioid antagonist or an equivalent amount of Free Base, prodrug, non hydrochloride, or mixture thereof, the opioid antagonist, wherein Said opioid antagonist Methylnaltrexone is naloxone, naltrexone and nalmefene, nalorphine, levalorfan,Oxilorfan or cyprenorphine; (b) an amount of Free Base nalbifina nalbuphine, Salt, prodrug of nalbuphine, or mixture thereof, which results in a Greater analgesia that nalbuphine Administration Component or component opioid antagonist alone; and (c) a vehicle AC Eptable for pharmaceutical use, being This composition formulated for mucosal Administration.