In the present invention, there is disclosed a pharmaceutical preparation in the form of a bilayer tablet containing: (a) a first discrete zone prepared from a mixture (A) that contains a therapeutically effective decongestant amount of a sympathomimetic medicament or pharmaceutically acceptable salt thereof in an amount of about 18 to about 39 percent by weight of formulation (A), and a first carrier base material, the first carrier base material comprising a mixture of: (i) carnauba wax; and (ii) a suitable antiadherent; wherein said first carrier base material provides a sustained release of the sympathomimetic medicament; and (b) a second discrete zone made with formulation (B) which comprises a therapeutically effective antihistaminic amount of a piperidinoalkanol, or a pharmaceutically acceptable salt thereof, in an amount of about 15 to about 30 percent by weight of formulation (B) and a second carrier base material, the second carrier base comprising a mixture of: (i) a cellulose diluent; (ii) pregelatinized starch; (iii) a suitable disintegrant; and (iv) a suitable lubricant; wherein said second carrier base material provides an immediate release of the piperidinoalkanol or the pharmaceutically acceptable salt thereof.
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