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Históndeasetýlasahemlar

机译:组蛋白二乙酰酶抑制剂

摘要

The invention concerns a compound of the formula (I); wherein Ring A is heterocyclyl; m is 0-4 and each RSUP1 /SUPis a group such as hydroxy, halo, trifluoromethyl and cyano; Ring B is ring such as thienyl, thiadiazolyl, thiazolyl, pyrimidyl, pyrazinyl, pyridazinyl and pyridyl; RSUP2 /SUPis halo and n is 0-2; and each RSUP4 /SUPis a group such as hydroxy, halo, trifluoromethyl and cyano; p is 0-4; and RSUP3 /SUPis amino or hydroxy; or pharmaceutically-acceptable salts or in-vivo-hydrolysable ester or amide thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by histone deacetylase.
机译:本发明涉及式(I)的化合物;其中环A是杂环基; m为0-4,各R 1 为羟基,卤素,三氟甲基和氰基等基团。环B是诸如噻吩基,噻二唑基,噻唑基,嘧啶基,吡嗪基,哒嗪基和吡啶基的环; R 2 为卤素,n为0-2;每个R 4 是羟基,卤素,三氟甲基和氰基等基团; p为0-4; R 3 是氨基或羟基;或其药学上可接受的盐或体内可水解的酯或酰胺;的制备方法,含有它们的药物组合物及其在治疗由组蛋白脱乙酰基酶介导的疾病或医学病症中的用途。

著录项

  • 公开/公告号IS7524A

    专利类型

  • 公开/公告日2004-11-11

    原文格式PDF

  • 申请/专利权人 ASTRAZENECA AB;

    申请/专利号IS20040007524

  • 申请日2004-11-11

  • 分类号A61K31/44;A61K31/495;A61K31/505;A61P17/06;A61P19/02;A61P19/08;A61P29/00;A61P35/00;C07D239/48;C07D241/26;C07D277/56;C07D401/04;

  • 国家 IS

  • 入库时间 2022-08-21 22:17:34

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