TEST AND MODEL FOR ALZHEIMER'S DISEASE.

摘要

A MODEL SYSTEM FOR ALZHEIMER'S DISEASE IS PRESENTED, INCLUDING A DNA SEQUENCE THAT CODIFIES AN ISOFORM OF AN AMYLOID PRECURSOR PROTEIN (APP) OR A FRAGMENT THAT HAS AN AMINO ACID REPLACEMENT. THE SUBSTITUTED AMINO ACID MAY BE DIFFERENT FROM THE VALINA IN THE POSITION OF THE AMINO ACID THAT CORRESPONDS WITH POSITION 717 OF THE AMINOACIDE RESIDUE OF APP 770. METHODS ARE ALSO PRESENTED TO DETERMINE THE GENETIC PREDISTION TO THE DISEASE OF ALZHEIM.