IMPROVED VIRUS LIKE PARTICLES BASED ON SMALL ENVELOPE PROTEIN FROM HEPATITIS B (HBSAG-S)

摘要

Isolated polynucleotides comprising a HBsAg-S coding sequence that is adapted to receive an insert coding sequence, within a part of the HBsAg-S coding sequence that encodes an exposed site within the external loop of HBsAg-S, and still encode a HBsAg-S that is able to assemble into a VLP. Proteins encoded by the polynucleotides, recombinant VLPs and various uses thereof are also described.