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Composition comprising the extract of Sophorae Radix or Prenylflavonoids having acyl CoA:diacylglycerol acyltransferase - inhibitory activity
Composition comprising the extract of Sophorae Radix or Prenylflavonoids having acyl CoA:diacylglycerol acyltransferase - inhibitory activity
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机译:包含具有酰基CoA:二酰基甘油酰基转移酶的槐属基或异戊二烯类黄酮提取物的组合物-抑制活性
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摘要
PURPOSE: Provided is a composition which inhibits the activity of acyl CoA: diacylglycerol acyltransferase (DGAT), and is well adapted for use in absorbing triglyceride, and treating the diseases due to the metabolic errors, such as lipodystrophy. CONSTITUTION: The composition comprises a crude extract or a nonpolar solvent extract of Sophorae Radix, or a prenyl flavonoid derivative compound expressed by formula I where R1 to R4 indicates H or other elements. The crude extract is a methanol extract, and the nonpolar extract is an ethyl acetate extract. The prenyl flavonoid derivative is kurarinone, sophoraflavanone G, kurarinol, kushenol H, kushenol K, kushenol B, kushenol M, kushenol E, or kushenol L.
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