COMPOSITION CONTAINING EXTRACT OF SOPHORAE RADIX OR PRENYL FLAVONOID COMPOUND WITH INHIBITION ACTIVITY OF ACYL COA:DIACYLGLYCEROL ACYLTRANSFERASE

摘要

PURPOSE: Provided is a composition which inhibits the activity of acyl CoA: diacylglycerol acyltransferase (DGAT), and is well adapted for use in absorbing triglyceride, and treating the diseases due to the metabolic errors, such as lipodystrophy. CONSTITUTION: The composition comprises a crude extract or a nonpolar solvent extract of Sophorae Radix, or a prenyl flavonoid derivative compound expressed by formula I where R1 to R4 indicates H or other elements. The crude extract is a methanol extract, and the nonpolar extract is an ethyl acetate extract. The prenyl flavonoid derivative is kurarinone, sophoraflavanone G, kurarinol, kushenol H, kushenol K, kushenol B, kushenol M, kushenol E, or kushenol L.