SILVER SALT 4-TOLUIDIDE 6-NITRO-2-IMINOCUMARIN-3-CARBONIC ACID, POSSESSING ANTI-MICROBIC ACTIVITY

摘要

FIELD: organic chemistry, medicine. ^ SUBSTANCE: invention relates to new compounds of coumarone class, namely, to 6-nitro-2-iminocoumarin 3-carboxylic acid 4-toluidide silver salt of the formula (1): that elicits an antibacterial effect and can be used in medicine. Invention provides preparing a new compound eliciting an antibacterial effect with respect to S. aureus, E. coli, and C. albicans with mononuclear cells values 0.25; 0.5 and 7.8 mcg/ml, respectively, and with acute toxicity value LD50 for these compounds 2 460 230 mg/kg. ^ EFFECT: valuable properties of compound. ^ 1 cl, 1 tbl, 2 ex