As a double transfected cell lines in - vitro - screening - tools for the production of profiles of pharmaceutical compounds: a model for the elimination of hepatobiliary

摘要

The present invention relates to a plurality of double transfected cell lines, the human ntcp (na / taurocholate cotran por ting protein; slc10a1) together with human bsep (bile salt export pump; abcb11) or human mrp2 (multidrug resistance protein; abcc2) express and as in vitro tool for profiling of pharmaceutical compounds, in particular as a model for the hepatobiliary elimination, are suitable.