Doubly transfected cell lines as in vitro screening instruments to produce pharmaceutical compound profile: model for hepatobiliary elimination of cell lineage transfectada with both NTCP human as human MRP2 suitable as an instrument, in vitro to produce p Erfil pharmaceutical compound model for hepatobiliary elimination:

摘要

Doubly transfected cell lines as in vitro screening instruments to produce pharmaceutical compound profile: model for hepatobiliary elimination of cell lineage transfectada with both NTCP human as human MRP2 suitable as a tool in vitro to produce PE Rfil of pharmacist: model for hepatobiliary elimination.The present invention relates to various lineages of cells doubly transfected to express human NTCP (protein co transport of Na / taurocolato; slc10a1) together with human BSEP (bile salt excretion pump; ABCB11) or human (MRP2 protein with resistance to multiple Drugs; ABCC2) suitable as a tool in vitro to produce pharmaceutical compound profile,Especially as a model for hepatobiliary elimination.