New hydrazide derivatives useful for treating or preventing disorders of lipid metabolism and cardiovascular disorders e.g. atherosclerosis, obesity, cerebral ischemia, type II diabetes and dyslipoproteinemia

摘要

Hydrazide derivatives (I) and their acid addition salts are new. Hydrazide derivatives of formula (I) and their acid addition salts are new. R 1, R 2H, 1-6C alkyl or 1-6C tri- to hepta-fluoroalkyl; A : mono- or poly-cyclic aryl or heteroaryl; B : optionally substituted phenyl. [Image] ACTIVITY : Antilipemic; Antiarteriosclerotic; Vasotropic; Anorectic; Antidiabetic; Cerebroprotective; Hepatotropic. 2-Cyclopropyl-4-quinolinecarboxylic acid (2-hydroxy-4,6-dimethoxybenzylidene)hydrazide (Ia) gave 81% inhibition of lipoprotein (LDLox; not defined) accumulation in THP1 cells at a concentration of 2.5 mu M. MECHANISM OF ACTION : None given.