Detection of serum Betatrophin in gestational diabetes mellitus patients and its correlation with glucose and lipid metabolism disorders

摘要

Objective: To detect the serum Betatrophin level in patients with gestational diabetes mellitus (GDM), and to explore the relationship between Betatrophin level and disorders of glucose and lipid metabolism. Methods: 119 cases of GDM women in our hospital during August 2015 to March 2018 were selected as GDM group, 100 cases pregnant women with normal blood glucose were chosen as Normal control group. Serum level of Betatrophin, glucose metabolism and lipid metabolism between two groups were compared. Pearson test was used to evaluate the relationship between Betatrophin, glucose and lipid metabolism disorders in GDM pregnant women. Results: Serum content of Betatrophin in GDM group was significantly higher than that in Normal control group, levels of HbA1c, FINS and HOMA-IR in peripheral blood were significantly higher than those in Normal control group; contents of TC, LDL-C and Apo-B in peripheral blood were higher than those in Normal control group, contents of HDL-C, Apo-A1 were lower than those in Normal control group. Correlation analysis showed that serum level of Betatrophin in GDM pregnant women was positively correlated with the disorder of glucose and lipid metabolism. Conclusion: Abnormally high expression of Betatrophin in GDM pregnant women may be an important factor in promoting disorder of glucose and lipid metabolism.