Effect of doubling-dose atorvastatin intervention on lipid metabolism, insulin resistance and carotid atherosclerosis in patients with type 2 diabetes mellitus

摘要

Objective:To study the effect of doubling-dose atorvastatin intervention on lipid metabolism, insulin resistance and carotid atherosclerosis in patients with type 2 diabetes mellitus. Methods:A total of 118 patients with type 2 diabetes mellitus treated in our hospital between May 2013 and December 2016 were collected, random number table was used to divide them into the single dose group (n=59) who received single-dose atorvastatin (20 mg/time, 1 times/d) therapy and the double dose group (n=59) who received doubling-dose atorvastatin (40 mg/time, 1 times/d) therapy, and both therapies lasted for 3 months. Serum levels of lipid metabolism indexes, insulin resistance indexes and carotid atherosclerosis-related indexes were compared between the two groups of patients before and after treatment.Results: Before treatment, differences in serum levels of lipid metabolism indexes, insulin resistance indexes and carotid atherosclerosis-related indexes were not statistically significant between two groups of patients. After treatment, serum lipid metabolism indexes TC, TG, FFA and LDL-C contents of observation group were lower than those of control group while HDL-C content was higher than that of control group; serum insulin resistance indexes INS and HOMA-IR levels were lower than those of control group while HOMA-β level was higher than that of control group; serum carotid atherosclerosis-related indexes visfatin, OPG, CysC and HMGB1 contents were lower than those of control group.Conclusions: Doubling-dose atorvastatin may be more effective in decreasing the hyperlipidemia and reducing the insulin resistance and carotid atherosclerosis in patients with type 2 diabetes mellitus.