Use of proteins of the uncoupling protein family or fragments thereof as active ingredients in cosmetic or dermatological compositions, e.g. slimming or anticellulite products

摘要

Proteins of the uncoupling protein (UCP) family or fragments thereof used as active ingredients in cosmetic or dermatological compositions, are new. Independent claims are also included for: (1) cosmetic, dermatological or pharmaceutical composition comprising a peptide as above; (2) cosmetic care method for reducing, eliminating or preventing excess subcutaneous fat and/or combating cellulite and/or combating the orange peel effect, comprising applying a composition as above to the skin. ACTIVITY : Dermatological; Anorectic. No biological data given. MECHANISM OF ACTION : Lipogenesis inhibitor. Pro-Leu-Asp-Thr-Ala-Lys-Val-Arg-Leu-Gln (0.5% of a 50 ppm solution) was added to cultures of 3T3-L1 pre-adipocyte cells before differentiation. On staining with oil red, the cells showed lower levels of lipid vesicles than control cells. No effect was observed if the peptide was added after differentiation.