DIAGNOSTIC METHOD OF AMYOTROPHY, EVALUATION METHOD OF ANTI-AMYOTROPHIC ACTION AND SCREENING METHOD OF ANTI-AMYOTROPHIC SUBSTANCE

摘要

PROBLEM TO BE SOLVED: To provide a diagnostic method of amyotrophy of high sensitivity, an evaluation method of anti-amyotrophic action using it and a screening method of an anti-amyotrophic substance using the evaluation method.;SOLUTION: The diagnosis of amyotrophy, the evaluation anti-amyotrophic action and the screening the anti-amyotrophic substance are performed using the development amount of oxidation stress inductive protein in a muscle as an index. As an example of the oxidation stress inductive protein, TNFα, pIkB, IL-8, MCP1, ICAM1 and 4-HNE modified protein are designated. The development amount of the oxidation stress inductive protein can be evaluated by measuring the amount of protein or mRNA. The same effect is also obtained using the development amount of myostatin and calcineurin in a muscle as an index.;COPYRIGHT: (C)2006,JPO&NCIPI