METHOD OF DIAGNOSIS hepatocellular carcinoma (SCC), PROCESS EVALUATION OF THE EFFECTIVENESS OF TREATMENT nucleotide sequence, protein, antibody and gene for PAC DIAGNOSTICS, METHOD FOR SCREENING COMPOUNDS FOR TREATMENT GAC METHOD FOR DIAGNOSIS OF INITIAL STAGES GAC nucleotide sequence PROTEIN ANTIBODY AND GENE FOR DIAGNOSIS OF THE INITIAL STAGE OF THE GAC, A METHOD FOR SCREENING THE CONNECTION FOR THE DIAGNOSTICS OF THE INITIAL STAGE OF THE GAC, A SOLID CARRIER, A SET AND KIT AS A MEANS FOR DIAGNOSTIC OF THE GAC AND THE INITIAL STAGE OF THE GAC

摘要

1. A method of diagnosing hepatic cell carcinoma (PAC) in vitro in a subject or assessing a subject's predisposition to develop PAC or to assess the prognosis of PAC in a subject or to determine the stage or severity of PAC in a subject, characterized in that the expression level is measured, at least , of a single gene in a liver tissue sample of said subject, said level of gene expression is compared with the level of expression of the same gene in a control sample and a decrease in said level of gene expression compared to exp resitions of the same gene in the control sample as a symptom of PAC, alternatively measure the level of at least one protein in the liver tissue sample of said subject, compare said protein level with the level of the same protein in the control sample, and consider a decrease in said expression level of the gene compared with the level of expression of the same gene in the control sample as a symptom of PAC, wherein said gene is selected from the group comprising a gene that encodes alcohol dehydrogenase (ADH) [ADH gene], a gene that encodes antioxidant protein 2 (AOP2) [AOP2 gene], a gene that encodes regularcalcin (SMP30) [SMP30 gene], a gene that encodes a non-specific sterol-transporting protein (NSLT) [NSLT gene], a gene that encodes sorbitol dehydrogenase (SDH) [ SDH gene], a gene that encodes serum albumin (SAP) [SAP gene], a gene that encodes phosphoglucomutase (PGM) [PGM gene], a gene that encodes phenylalanine-4-hydroxylase (P4H) [P4H gene], a gene that encodes apolipoprotein A1 (APOA1) [APOA1 gene], a gene that encodes carbonic anhydrase III (CAIII) [CAIII gene], a gene that encodes mitochondrial aldehyde