Molecules inhibiting hepatitis c virus protein synthesis and method for screening same

摘要

The invention concerns a method for screening molecules which consists, in vitro: a) in incubating together the subunit p116 (SEQ ID4) of the elF3 protein, the nucleotide sequence of region II (SEQ ID2) of the HCV IRES or any sequence containing at least 10 successive nucleotides of the region II (SEQ ID2) of the HCV IRES and the molecule to be tested; b) in detecting the possible formation of p116/IRES region II complex, the absence of complex indicating the inhibiting capacity of the tested molecule, to inhibit the formation of said complexes; c) in selecting the molecules inhibiting the formation of complexes.