Fluoroglicosidicos Derivatives of pyrazoles with Inhibitory activity of SGLT 1, medicaments containing these compounds and their use in the treatment of Type I and Type II diabetes.

摘要

These compounds are appropriate, for example, as a drug for the treatment of type I and type II diabetes. Item 1: a formula compound (1), wherein R1 and R2 independently mean,F or h, definitely one of the R1 or R2 radicals; a means o, NH, CH2, s or link; R3 means h, F, Cl, Br, I, oh, CF3, NO2, CN, cooph, co - (C1-6 tar),COO (C1-6 tar)CONH 2, CONH - (C1-6 asphalt)And (C1-6) 2, C1-6, C1-6, cycloquilo C3-6, alquenilo c2-6, c12-6, or - (C1-6, hydrocarbon),Ho - (C1-6 tar)(C1-6) - O - (C1-6 asphalt)1. Benzene, benzene (Alcoy C1-6) - carbide, can be replaced by one or more f or all h of tar, acyl chloride, tar and o-tar; so2-nh2, so2-nh (C1-6 tar);So2n (C1-6 tar) 2, s - (C1-6 tar),S - (CH2) o-phenyl, so - (C1-6 tar),So - (CH2) o-phenyl, SO2 - (C1-6 tar),SO2 - (CH2) o-phenyl has the value of 0-6 or 0-6, and can be replaced by F, Cl, Br, oh, CF3, NO2, CN, ocf3 or - (C1-6 tar) up to twice;C1-6, NH2; NH2, NH - (C1-6 tar),N (C1-6 tar) 2, nh-co - (c1-7 tar),1. Phenyl, O - (CH2) or - phenyl, having the value of 0-6 or 0-6, and the phenyl ring can be replaced one to three times, with F, Cl, Br, I, oh, CF3, NO2, CN, ocf3, or - (C1-6 tar),C1-6, NH2, NH (C1-6 tar),N (C1-6 tar) 2, so2-ch3, COOH, COO - (C1-6 tar),CONH2; R4 refers to h, C1-6 asphalt, c2-6 alquenilo C3-6, or phenyl which can be replaced by C1-4 halogen or aspha B refers to c0-15 asphalt, which can be replaced independently by one or more asphalt C atoms,I am me.- (C 3DO) --CH=CH---C::C--- yes.-Ch (OH)- Shh...-CF2...- (S 3DO) -- (SO2) --N (C1-6 tar) -,-N ((C1-6) - phenyl) - o-nh -;R5, R6, R7 stand for independence,H. F, Cl, Br, I, oh, CF3, NO2, CN, COO h, COO (C1-6 tar),2. CO (C1-4 tar);CONH 2, CONH (C1-6 asphalt)And (C1-6) 2, C1-6, C1-6, alquenilo c2-6, c2-6, or - (c1-8, asphalt),Hu - (C1-6) - O - (pitch C1-6)It may be replaced by more than one f, or all h from the radical tar, aluminum, tar and o-tar; so2-nh2, so2nh (C1-6 tar),So2n (C1-6 tar) 2, s - (C1-6 tar),S - (CH2) o-phenyl, ScF3, so - (C1-6 tar),So - (CH2) o-phenyl, SO2 (C1-6 tar),SO2 - (CH2) o-phenyl has or may have a value of 0-6, and can be replaced by F, Cl, Br, oh, CF3, NO2, CN, ocf3 or - (C1-6 tar) for up to two times,C1-6, NH2; NH2, NH - (C1-6 tar),N (C1-6 tar) 2, nh-co - (C1-6 tar),1. Phenyl, O - (CH2) or - phenyl, having the value of 0-6 or 0-6, and the phenyl ring can be replaced one to three times, with F, Cl, Br, I, oh, CF3, NO2, CN, ocf3, or - (c1-8 tar),C1-6, NH2, NH (C1-6 tar),N (C1-6 tar) 2, so2-ch3, COOH, COO - (C1-6 tar),C12; or R6 and R7, together with the C atom supporting them, refer to a 5-7-ring, saturated, partially unsaturated, unsaturated or completely unsaturated CC1. The 1-2 C atoms of the ring may also be replaced by N, O or s, and CC1 can be replaced by C1-6 tar or alquenilo c2-5, C2-5 tar, in which case a CH2 group may have been replaced or replaced by H, F, Cl, oh, CF3, NO2, CN, COO (C1-4 tar),CONH 2, CONH (C1-4 tar)X means Co, O, NH, s, so, SO2 or link; l means asphalt C1-6, alquenileno c2-5, c12-5, asphalt c2-5, which may be replaced by NH or NH respectively by one or two CH2 groups; and it means Co, nhco, so, SO2, or link; R8, R9 means independent,H. SO3H, massive sugar, C1-6 tar, can be independently replaced by one or more different tar CH2 groups,And C1-6, oh, (tar C1-6) - Oh, (alquenilen c2-6) - Oh, O - (sugar radical).Oso3h, NH2, NH - (C1-6 tar)N (C1-6 tar) 2, nh-co - (C1-6 tar),NH - (sugar radical)Nh-so3h (asphalt C1-6) - NH2 (alquenilen c2-6) - NH2 (asphalt c0-6) - NH2 (asphalt c0-6) - COH (asphalt c0-6) - CONH2 (asphalt c0-6) - CONH - (asphalt C1-6),(pitch c0-6) - sonh2 (pitch c0-6) - sonh - (pitch C1-6),(tar c0-6) - 2nh2 (tar c0-6) - 2nh (tar C1-6, adamantilo; or R8 and R9, together with the N atoms that support them, means that a ring of 5 to 7 rings, saturated, C22, may also be replaced by one or more CH2 groups with O, s, NH, ns3h, N - (glycoradical type),N - (C1-6 tar)One or more CH2 groups of infrastructure may be replaced independently of each other,And C1-6, ha ha, (tar C1-6) - Oh, (alquenilen c2-6) - Oh, NH2, NH - (tar C1-6),N (C1-6 tar) 2, nh-co - (C1-6 tar, NH - (sugar radical type),(asphalt company C1-6) - NH2 (alquenilen c2-6) - NH2 (asphalt company c0-6) - COOH (asphalt company c0-6) - CONH2 (asphalt company c0-6) - CONH - (asphalt company C1-6),(pitch c0-6) - sonh2 (pitch c0-6) - sonh - (pitch C1-6),(tar layer C0-6) -SO2NH2 (tar layer C0-6) -SO2NH- (tar layer C1-6);And medically acceptable salts.