Procedure for obtaining a Derivative of 11 - (4 - (1-piperazinyl) dibenz (B, f) (1.4) thiazepine.

摘要

Procedure for obtaining a Derivative of 11 - (4) - 1-piperazinyl) dibenzo [B, F] [1,4] thiazepine, fu00f3rmu00fala general I, which means Hydrogen or a Group - (CH2) 2 - Oh group or a - (CH2) 2 - or - (CH2 2 - Oh), or a Salt thereof, comprises a step in which REACT with 10h - Dibenzo [B, F] [1,4] thiazepin-11 - ona, a Derivative of piperazineIn the presence of a Titanium alkoxide, of General formula ti (OR) 4, where r is an alkyl group, linear or branched, one to eight carbon ATOMS, to obtain the Derivative of formula (i) or a Salt thereof.In the case that a is - (CH2) 2 - or - (CH2) 2 - Oh, then the Derivative of piperazine is 1 - (2 - (2-hydroxyethoxy) ethyl) piperazine derivative 11 - (4 - 1-piperazinyl) dibenzo [B, F] [1,4] thiazepine is quetiapine (11 - (4 - (2 - (2-hydroxyethoxy) ethyl) - 1-piperazinyl) dibenzo [B, F] [1,4] thiazepine).The procedure may include an additional stage of reaction of Quetiapine with fumaric acid to obtain Quetiapine hemifumarate.