[PROBLEMS] To provide a method of inhibiting the phosphorylation of a transcriptional factor for a gluconeogenesis-associated gene and a phosphorylation inhibitor. [MEANS FOR SOLVING PROBLEMS] By finding out that a transcriptional factor HNF-4α is phosphorylated by RSKB and the binding thereof to the promoter region of a gluconeogenesis-associated gene is promoted thereby, it is intended to provide: a method of phosphorylating HNF-4α by RSKB, a method of inhibiting the phosphorylation and a phosphorylation inhibitor; a method of producing a gene product of a gene on which HNF-4α acts as a transcriptional factor, a production inhibitor and a method of inhibiting the production; a drug for preventing and treating a disease caused by the phosphorylation of HNF-4α by RSKB and a method for preventing and treating the same; a method of identifying a compound inhibiting the interaction between RSKB and HNF-4α, the phosphorylation of HNF-4α by RSKB or the binding of RSKB to HNF-4α; a compound obtained by the identification method; a polynucleotide encoding RSKB, HNF-4α or RSKB or HNF-4α; and a reagent kit containing a vector having this polynucleotide.
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