REGULATION OF PROCASPASE-2 ACTIVATION BY PHOSPHORYLATION OF PROCASPASE-2

摘要

Disclosed are a composition for inducing apoptosis comprising a substance blocking procaspase-2 phosphorylation and TNF-related apoptosis-inducing ligand (TRAIL) and a method of inducing apoptosis using the composition. Also disclosed is a method of detecting a substance regulating phosphorylation of procaspase-2, comprising (a) contacting procaspase-2 with a candidate substance regulating phosphorylation of procaspase-2 and (b) measuring phosphorylation of procaspase-2. Further disclosed is a procaspase-2 variant protein which has at least one substitution of a nonpolar amino acid for the 140th serine residue and 0 to 3 serine residues at positions 63, 65 and 147.