Hormone Regulation of Tissue Type Piasminogen Activator （tPA） and Plasminogen Activator Inhibitor Type I （PAI-I） Gene Expression in the Ovaries During Gonadotropin-induced Ovulation

摘要

The plasminogen-activator system provides proteolytic activity in many biological processes . The regulation of plasminogen activation may occur at many levels in-cluding the synthesis and secretion of plasminogen activators (PA) and the specific in-hibition of PA activity by inhibitors. PA-inhibitor o,pe-1 ( PAI-1) is an efficientinhibitor of tissue-type PA (tPA) and urokinase-type PA (uPA) that may thereforebe instrumental for the control of plasminogen activation . To investigate whethercoordinated regulation of PA an PA inhibitors would take place in vivo in response tophysiological signals, we have examined the regulation of tPA and PAI-1 in the ovaryduring gnnadotropin-induced ovulation.