NSAID COMPOSITIONS EXHIBITING CLINICAL SUPERIORITY

摘要

The invention is directed to a composition and its use in treating pain, pyrexia and inflammation comprising an NSAIS as the active ingredient, a metasilicate, a first disintegrant and second disintegrant resulting in increased absorption of poorly soluble NSAIS’s and increased absorption in suppressed vagal systems. The preferred composition comprises ibuprofen on a metasilicate matrix, sodium bicarbonate as the first disintegrant and tartaric acid as the second disintegrant. The composition may also contain additional pharmaceutically acceptable excipients.