ADENOVIRUS VECTOR PRODUCING ANTISENSE TELOMERASE AND THE METHODS FOR PROLIFERATION AND DIFFERENTIATION OF HEMATOPOIETIC STEM CELL

摘要

The present invention relates to an adenovirus that produces an antisense capable of inhibiting telomerase enzyme activity associated with self-renewal of hematopoietic stem cells, and use thereof for promoting hematopoietic stem cell differentiation and proliferation. Specifically, the present invention relates to an adenovirus vector capable of inhibiting the activity of telomerase essential for self-renewal in stem cells, including hematopoietic stem cells, and an application thereof, wherein the adenovirus clone Ad-OA of the present invention Through differentiation / proliferation, it can be usefully applied to supply of immune cells for cell therapy and production of artificial blood.