TRANSGENIC DEMENTIA MICE EXPRESSING THE MUTAGENIC APP/C-105 GENE

摘要

invention APP/C-105 gene expression in transgenic Alzheimer mice on that, more specifically, - secretase APP gene as a Hydratase ( -secretase) is cut by enzymes of the human being consists of 56-63 amino acids and 42 amino acids in the neighboring carboxyl-terminal fragment of looking derived from APP / C-105-induced dementia genes and then NSE-specific gene promoter prepared by connecting a micro-fusion genes in the fertilized egg implanted in the brain of a mouse, this mouse embryos are implanted in the oviducts of surrogate relates to transgenic mice that produce dementia. ; Alzheimer transgenic mouse according to the present invention, as the expression of toxicity of the expressed protein and increase its binding proteins, such as human GSK3 and dementia of the Alzheimer's symptoms similar to brain dysfunction, and the amyloid -42 appears, a therapeutic agent of Alzheimer's disease or it can be used particularly useful in early diagnosis of Alzheimer's disease development.