/-105 Transgenic dementia mice expressing the mutagenic APP/C-105 gene

摘要

The present invention relates to a transgenic Alzheimer mice expressing APP / C-105 gene, and more specifically by - secretase matriptase the APP gene ( -secretase) is cut by enzymes of the human being consists of 56-63 amino acids and 42 amino acids that are adjacent to the carboxyl-terminal fragment of looking-derived APP / C-105 genes induced dementia then connect the NSE-specific promoter of the gene fusion gene prepared by the microinjection of fertilized mouse brain, the fertilized eggs are implanted in a surrogate mother mouse oviduct relates to transgenic mice that produce dementia. ; Alzheimer transgenic mouse according to the present invention, as the expression of toxicity of the expressed protein and increase its binding proteins, such as human GSK3 and dementia of the Alzheimer's symptoms similar to brain dysfunction, and the amyloid -42 appears, a therapeutic agent of Alzheimer's disease or can be used very useful for early diagnosis of Alzheimer's disease development.