TRANSGENIC DEMENTIA MICE EXPRESSING MUTANT PS2 GENE CAPABLE OF BEING UTILIZED USEFULLY IN TREATING A DEMENTIA DISEASE OR IMPROVING AN EARLY DIAGNOSIS PROCESS OF THE DISEASE

摘要

PURPOSE: A transgenic dementia mouse expressing a mutant PS2 gene and a manufacturing process thereof are provided to be utilized usefully in treating a dementia disease or improving an early diagnosis process of the disease. CONSTITUTION: The manufacturing process of the transgenic dementia mouse expressing a mutant PS2 gene comprises the steps of: preparing a hybrid gene NSE/hPS2m by connecting to a promoter of a neuron-specific enolase gene to a mutant PS2 dementia gene derived from a human; micro-injecting the hybrid gene into a fertilized egg of a mouse; and implanting the fertilized egg into an oviduct of a surrogate mother mouse.