2 Transgenic dementia mice expressing PS2 mutant gene and TAKtetracycline transactivator gene

摘要

The invention hPS2 mutant gene and TAK (tetracycline transactivator) relates to a double transgenic Alzheimer mice expressing the gene, more specifically, a promoter of the recombinant gene and pTet gene was connected to a promoter (promoter) of pTet gene in TAK gene ( micro-injection, respectively of mouse embryos recombinant gene was connected to the hPS2m gene promoter) (microinjection), and producing a transgenic mouse produced by transplantation of the fertilized eggs to a surrogate mother mouse fallopian tube (oviduct), and the transgenic mice It relates to a double transgenic mouse produced by mating dementia. ; Transgenic Alzheimer mice according to the invention to exhibit characteristics such as the PS2 possible expression control of the gene, and activation of the symptoms of dementia and similar behavioral abnormalities and amyloid β-42 accumulation and Tau protein in human patients with dementia, the activation of catenin , it can be very useful in the use early development of diagnostic or therapeutic agents of Alzheimer's disease dementia. ; Dementia, Alzheimer's disease * * * PS2 * tetracycline-induced dementia mice amyloid β-42 * Tau protein -catenin *