CARBAMINIC ACID DERIVED CONTENT OF AN AMID GROUP AS HDAC INHIBITOR

摘要

This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: CHEM wherein: A is an aryl group; Q1 is an aryl leader group having a backbone of at least 2 carbon atoms; J is an amide linkage selected from: -NR1C(=O)- and -C(=O)NR1-; R1 is an amido substituent; and, Q2 is an acid leader group; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof, for use in the treatment of parasitic infections, such as malaria.