Metal-Free Direct Amidation of Naphthoquinones Using Hydroxamic Acids as Amides Source: Application in The Synthesis of A HDAC6 Inhibitor

摘要

A novel synthetic approach to amido-quinones by the reaction of naphthoquinones with hydroxamic acids under basic conditions was developed. The reaction is mild and operationally simple, and it affords high yields of amido-quinones. With this new method, a novel highly strong HDAC6 inhibitor, which showed high toxicity to AML cells, was successfully synthesized.