COMPOUND COMPRISING A POLYMER, A SPACER AND AN ACTIVE INGREDIENT, COMPOSITION CONTAINING THE COMPOUND AND USES

摘要

A new compound (I) comprises active agent(s) (A) having an active site (AS), a spacer (SP) and a polymer (PL), (A) being in inactive form when bonded to (PL) via (SP), where: (i) (A) is released from (SP), by cleavage at (AS), in presence of enzyme released by a microorganism; and (ii) (AS) is selected from about 50 specific groups, e.g. carboxylic or sulfonic acid, alcohol, amine, thiol or ester. A new compound (I) comprises active agent(s) (A) having an active site (AS), a spacer (SP) and a polymer (PL), (A) being in inactive form when bonded to (PL) via (SP), where: (i) (A) is released from (SP), by cleavage at (AS), in presence of enzyme released by a mcroorganism; and (ii) (AS) is selected from alkene, diene, alkyne, alcohol, carboxylic acid, ester, anhydride, aldehyde, ketone, aldo-ketene, keto-ketene, ether, epoxide, peroxide, hemiacetal, acetal, amine, hydrazine, amide, imine, imide, hydroxylamine, hydroxamic acid, oxime, hydrazone, hydrazide, nitrile, isocyanate, azo, azidocarbonyl, nitro, nitrate, sulfenic acid, sulfinic acid, sulfonic acid, sulfate, sulfone, sulfoxide, thioacid, thioketone, thioester, thiol, thioether, disulfide, acid halide, ether halide, sulfenyl, halide sulfonyl halide or nitrite ion. Independent claims are included for: (a) the preparation of (I), by reacting (A) with (SP) and (PL); (b) cosmetic, dermatological or pharmaceutical compositions comprising (I) in a suitable medium; and (c) a cosmetic treatment method for the skin or hair, involving application of a (I)-containing composition.