CERAMIC MICROARRAY SPOTTING DEVICE FOR BIOASSAY PRINTING

摘要

Methods of making and the resultant micro-spotting plates having a plurality of feed holes, a plurality of dispensing nozzles, an open cavity in communication with the dispensing nozzles and a plurality of channels. The channels connect the feed holes to the dispensing nozzles for transferring a fluid from the feed holes to the dispensing nozzles under a capillary force. A channel may connect a single feed hole retaining a liquid to a dispensing nozzle for dispensing such liquid, or a channel may connect two or more feed holes to a dispensing nozzle for enabling mixing of fluids from the feed holes within the channel prior to dispensing such mixture. The micro-spotting plates allow the continuous self-feeding flow of fluids by capillary forces through its hydrophilic layers for enabling the controlled dispensing of a multi-array of drops of fluids onto a substrate, preferably a test slide, for later use.