methods of selectively inducing apoptosis in dr5-expressing target cells, inhibiting proliferation of dr5-expressing target cells, and treating a patient having an inflammatory disease or autoimmune disease;

摘要

"METHODS OF SELECTIVELY INDUCING APOPTOSIS IN TARGET CELLS EXPRESSING DR5, INHIBITING PROLIFERATION OF TARGET CELLS EXPRESSING DR5, AND TREATING A PATIENT HAVING AN INFLAMMATORY DISEASE OR AUTOIMMUNE DISEASE, AND. An antibody of the invention interacts with human DR5 or human DR4 to produce downstream receptor agonistic or antagonistic effects including inhibition of cell proliferation and apoptosis. Methods and uses for antibodies, optionally in combination with various therapeutic agents, are detailed, including treatment of apoptosis-related disease and treatment of unregulated cell development.