hematopoietic stem cells and methods of treating neovascular eye diseases with the same

摘要

HEMATOPOETIC BODY CELLS AND METHODS OF TREATMENT OF NEOVASCULAR EYE DISEASES WITH THE SAME These are populations of negative lineage stem cell derived from mammalian bone marrow (Lin med B contêmHSC) capable of endothelial progenitor (EPC) cells form retinal blood vessels. At least about 50% of the cells in the Lin¬ B¬HSC population include the CD31 and c-kit cell surface markers. Up to about 8% of cells may include the Sca-1 marker, and up to about 4% of cells may include F1K-1 / KDR marker. Isolated Lin¬ B¬HSC populations of the present invention are useful for treating ocular vascular diseases. Isolated Lin¬ B¬HSC populations that have been transfected with therapeutically useful genes are also proportional, which are useful for gene delivery in the eye for cell-based gene therapy.