REDIRECTION OF CELLULAR IMMUNITY BY RECEPTOR CHIMERAS

摘要

Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal at least two chimeric receptors which trigger the specific recognition and destruction of an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an autoimmune-generated cell. One of the expressed chimeric receptors includes an extracellular portion which is capable of specifically recognizing and binding the target cell or target infective agent and an intracellular or transmembrane portion which is capable of signalling the therapeutic cell to destroy a receptor-bound target cell or a receptor-bound target infective agent; and the second chimeric receptor includes an extracellular portion which is capable of specifically recognizing and binding the target cell or target infective agent and an intracellular portion which is derived from CD28. Also disclosed are pairs of useful chimeric receptors, cells which express the chimeric receptors, and DNA encoding the chimeric receptors.