EP RECEPTOR SUBTYPE-DEPENDENCE OF REGULATION OF IMMUNE CELLULAR FUNCTIONS BY PROSTAGLANDIN E2~a

摘要

The recognition that some eicosanoids are potent inflammatory mediators was based on initial findings of the smooth muscle, microvascular, epithelial cell and nociceptive neural effects of prostaglandins (PGs) and peptidoleukotrienes, which mimicked the major humoral manifestations of tissue inflammation (1-3). The leukocytic component of inflammation also was shown to be reproduced by leukotriene B4 (LTB4) and several di-hydroxy-eicosatetraenoic acids (di-HETEs) from the 15-lipoxygenase (15-LO) pathway, with only modulatory influences of cyclooxygenase products, peptidoleukotrienes and lipoxins (4,5).