A method for the preparation of crystalline lapathinia and the measurement of the crystallization of lapathinia compounds by differential scanning calorimetry

摘要

It refers to a raphamincina process purified by CCI-779 (temsirolimus) crystal, which includes: (a) heating the raw raphamincina to 55 ° C aprox. And filter; (b) add heptabromodiphenyl ether within 60 minutes. (c) At a constant speed; (c) reduce the vibration speed to about 7 C to 8 C and cool to 9 C / h at different speeds;(d) The product was filtered to obtain Rapamicin. It also refers to a method to determine the particle mass of the halo compound with the heat of differential scanning quantity, and the particle mass is directly proportional to the thermal fusion temperature of the sample.