PROCESS FOR INCREASING THE WATER SOLUBILITY OF LIPOPHILIC ACTIVE SUBSTANCES; PREPARATION OF HIGHLY CONCENTRATED AQUEOUS COMPOSITIONS OF SUCH ACTIVE SUBSTANCES; SUCH PRODUCTS AND THEIR USE

摘要

The invention relates to a method for increasing the solubility of lipophilic, active substances in aqueous systems and to the corresponding production of highly concentrated aqueous compositions of lipophilic active substances, selected from hormones, hormone analogs, terpenes, imidazoles, resins and derivatives thereof. According to the inventive method, an alcoholic solution of the one or more active substances is mixed with vesicle-forming lipids. The composition so obtained is then reacted with a gel-containing mixture, thereby obtaining highly concentrated compositions that can be topically administered directly as such in the form of gels or that can be lyophilized. In the latter case, powders are obtained that can be processed, depending on the desired application, to for example creams, gels, ointments, adhesive dressings, solutions, capsules, tablets, granules, etc. The inventive method allows to incorporate such lipophilic active substances in high amounts and to obtain a storage-stable form that can be easily transported.