USEFUL AMINOTETRAZOL DERIVATIVES AS INHIBITORS OF NITRICO SINTASA OXIDE.

摘要

A compound having the ** formula ** and pharmaceutically acceptable salts thereof; where ; R1, R2 are independently selected from the group consisting of hydrogen, C1-C10 alkyl, C2-C10 alkenyl and C2-C10 alkynyl; R3, R4 are independently selected from the group consisting of C1-C10 alkyl, C2-C10 alkenyl and C2-C10 alkynyl, OR6 wherein R6 is hydrogen, C1-C10 alkyl, C2-C10 alkenyl and C2-C10 alkynyl, COR7, or SO2R8 wherein R7 and R8 are independently selected from the group consisting of C1-C10 alkyl, C2-C10 alkenyl and C2-C10 alkynyl; X is selected from the group consisting of C1-C10 alkyl, C2-C10 alkenyl and C2-C10 alkynyl all of which may be optionally substituted with C1-C10 alkyl, C1-C10 alkoxy, hydroxy, halogen, trifluoromethyl, nitro, cyano, Not me; or X is selected from the group of the formula ¿(CH2) pQ (CH2) r- where p is 1 to 3, r is 1 to 3 and Q is oxygen, C = O, S (O) t where t is 0 to 2, or NR12 wherein NR12 is hydrogen or C1-C10 alkyl which may be optionally substituted with C1-C10 alkyl, C1-C10 alkoxy, hydroxy, halogen, trifluoromethyl, nitro, cyano, amino; or X is selected from the group of formula - (CH2) sA (CH2) v- where s is 0 to 2, v is 0 to 2 and A is a 3 to 6 membered carboxylic radical that can be optionally substituted with C1- C10 alkyl, C1-C10 alkoxy, hydroxy, halogen, trifluoromethyl, nitro, cyano, amino wherein all said radicals are optionally substituted with hydrogen, halogen and C1-C10 alkyl; Y is selected from the group consisting of C1-C10 alkyl, C2-C10 alkenyl, and C2-C10 alkynyl or Y can be NR9R10 wherein R9 and R10 are independently selected from the group consisting of hydrogen, C1-C10 alkyl, C2- C10 alkenyl, alkynyl, nitro, amino, aryl, and C1-C10 alkaryl.