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GASTROKINETIC MONOCYCLIC BENZAMIDES OF 3- OR 4-SUBSTITUTED 4-(AMINOMETHYL)-PIPERIDINE DERIVATIVES
GASTROKINETIC MONOCYCLIC BENZAMIDES OF 3- OR 4-SUBSTITUTED 4-(AMINOMETHYL)-PIPERIDINE DERIVATIVES
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机译:3-或4-取代的4-(氨基甲酰基)-哌啶碱衍生物的胃肠动力学单环苯甲酰胺
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摘要
The present invention of compounds of formula (I), a stereochemically isomericform thereof, an N-oxide form thereof or apharmaceutically acceptable acid addition salt thereof, R1 is C1-6alkyloxy, C2-6alkenyloxy or C2-6alkynyl-oxy; R2 is hydrogen, C1-6alkylC1-6alkyloxy; R3 is hydrogen or halo; R4 is hydrogen or C1-6alkyl; R5 ishydrogen or C1-6alkyl; L is C3-6cycloalkyl, C5-6cycloalkanone,C2-6alkynyl, or L is a radical of formula -A1-R6-, A1-X-R7, -A1-Y-C(=O)-R9, or-A1-Y-C(-O)-NR11R12 wherein each A1 isC1-12alkanediyl; and R6 is hydrogen, cyano, C1-6alkylsulfonylamino, C3-6cycloalkyl, C5-6cycloalkanone, or a heterocyclic ring system;R7 is hydrogen, C1-6alkyl, hydroxy C1-6alkyl, C3-6cycloalkyl, or aheterocyclic ring system; X is O, S, SO2 or NR8; said R8 being hydrogenor C1-6alkyl; R9 is hydrogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkyloxy orhydroxy; Y is NR10 or a direct bond; said R10 being hydrogen,or C1-6alkyl; R11 and R12 each independently are hydrogen, C1-6alkyl, C3-6cycloalkyl, or R11 and R12 combined with the nitrogen atommay form an optionally substituted pyrrolidinyl, piperidinyl, piperazinyl or 4-morpholinyl ring. Processes for preparing said products,formulations comprising said products and their use as a medicine aredisclosed, in particular for treating conditions which are related toimpairment of gastric emptying.
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