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CRYSTAL STRUCTURE OF A BACTERIAL HOMOLOGUE OF NA(+) CL(-)-DEPENDENT NEUROTRANSMITTER TRANSPORTERS
CRYSTAL STRUCTURE OF A BACTERIAL HOMOLOGUE OF NA(+) CL(-)-DEPENDENT NEUROTRANSMITTER TRANSPORTERS
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机译:NA(+)CL(-)依赖性神经递质转运蛋白的细菌同源性的晶体结构
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摘要
The present invention relates to three dimensional structural models of the LeuTAa transporter, and, in particular, the modeled sites of these proteins. The structural information of the present invention may be used for the rational design of compounds which act as modulators of the LeuTAa transporter and its eukaryotic counterparts. The present invention further provides for actual or virtual screening assays which may be used to identify compounds having such modulator activities, or to confirm the activity of designed compounds.
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