PHARMACEUTICAL COMPOSITION COMPRISING SILYMARIN FOR PREVENTION AND TREATMENT OF IRRITANT CONTACT DERMATITIS

摘要

The present invention relates to a pharmacological composition containing silymarin for the prevention and cure of irritant contact dermatitis. More specifically, the inventive composition containing silymarin or its main ingredients, silybin, silydianin and silychristin suppress symptoms of irritant contact dermatitis induced from an application of 1-chloro-2,4-dinitrobenzene on mouse ears such as swelling and increases in the water contents of the ears, weight increases in the lymph nodes and upregulated expression of TNF-α The pharmacological compositions of this invention are thus useful in the prevention and cure of irritant contact dermatitis.