METHODS FOR BUILDING ATOMIC MODELS OF PROTEIN MOLECULES AND DETERMINING DRUG CANDIDATES USING MGST1

摘要

Methods for building an atomic model of a protein molecule comprising: (a) identifying a protein molecule with at least 20% sequence identity with Microsomal Glutathione Transferase 1 (MGSTl) and (b) utilizing the atomic coordinates of MGSTl to obtain an atomic model of the identified protein molecule and methods for determining a drug candidate compound that interacts with members of the MAPEG superfamily, in particular MGSTl are also provided.